Sample Size Formula (approximate):
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This calculator provides an approximate sample size calculation when planning studies where the median will be used as the primary measure of central tendency. It uses a modified version of the standard sample size formula adjusted for median-based analysis.
The calculator uses the formula:
Where:
Explanation: This formula provides an approximate sample size needed to estimate the median with specified precision and confidence level.
Details: Proper sample size calculation ensures your study has adequate power to detect meaningful effects while avoiding unnecessary resource expenditure on overly large samples.
Tips:
Q1: How accurate is this for median calculations?
A: This provides an approximation. For exact median calculations, more complex methods may be needed.
Q2: What Z-score should I use?
A: Common values: 1.645 (90% CI), 1.96 (95% CI), 2.576 (99% CI).
Q3: How to estimate standard deviation?
A: Use pilot data, similar studies, or literature values. For new measures, consider a range of plausible values.
Q4: What if my data isn't normally distributed?
A: This formula works best for approximately normal distributions. For highly skewed data, consider non-parametric alternatives.
Q5: Should I adjust for expected dropout?
A: Yes, increase your calculated sample size by your anticipated dropout rate (e.g., if n=100 and 10% dropout expected, recruit 111 participants).